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- Title
Breast cancer risk for noncarriers of family-specific BRCA1 and BRCA2 mutations: findings from the Breast Cancer Family Registry.
- Authors
Kurian, Allison W; Gong, Gail D; John, Esther M; Johnston, David A; Felberg, Anna; West, Dee W; Miron, Alexander; Andrulis, Irene L; Hopper, John L; Knight, Julia A; Ozcelik, Hilmi; Dite, Gillian S; Apicella, Carmel; Southey, Melissa C; Whittemore, Alice S
- Abstract
Women with germline BRCA1 and BRCA2 mutations have five- to 20-fold increased risks of developing breast and ovarian cancer. A recent study claimed that women testing negative for their family-specific BRCA1 or BRCA2 mutation (noncarriers) have a five-fold increased risk of breast cancer. We estimated breast cancer risks for noncarriers by using a population-based sample of patients with breast cancer and their female first-degree relatives (FDRs).
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Vol 29, Issue 34, p4505
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2010.34.4440