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- Title
R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study.
- Authors
Pappo, Alberto S; Patel, Shreyaskumar R; Crowley, John; Reinke, Denise K; Kuenkele, Klaus-Peter; Chawla, Sant P; Toner, Guy C; Maki, Robert G; Meyers, Paul A; Chugh, Rashmi; Ganjoo, Kristen N; Schuetze, Scott M; Juergens, Heribert; Leahy, Michael G; Geoerger, Birgit; Benjamin, Robert S; Helman, Lee J; Baker, Laurence H
- Abstract
The type 1 insulin-like growth factor 1 receptor (IGF-1R) has been implicated in the pathogenesis of the Ewing sarcoma family of tumors (ESFT). We conducted a multicenter phase II study of the fully human IGF-1R monoclonal antibody R1507 in patients with recurrent or refractory ESFT.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Vol 29, Issue 34, p4541
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2010.34.0000