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- Title
mRNA expression signature of Gleason grade predicts lethal prostate cancer.
- Authors
Penney, Kathryn L; Sinnott, Jennifer A; Fall, Katja; Pawitan, Yudi; Hoshida, Yujin; Kraft, Peter; Stark, Jennifer R; Fiorentino, Michelangelo; Perner, Sven; Finn, Stephen; Calza, Stefano; Flavin, Richard; Freedman, Matthew L; Setlur, Sunita; Sesso, Howard D; Andersson, Swen-Olof; Martin, Neil; Kantoff, Philip W; Johansson, Jan-Erik; Adami, Hans-Olov; Rubin, Mark A; Loda, Massimo; Golub, Todd R; Andrén, Ove; Stampfer, Meir J; Mucci, Lorelei A
- Abstract
Prostate-specific antigen screening has led to enormous overtreatment of prostate cancer because of the inability to distinguish potentially lethal disease at diagnosis. We reasoned that by identifying an mRNA signature of Gleason grade, the best predictor of prognosis, we could improve prediction of lethal disease among men with moderate Gleason 7 tumors, the most common grade, and the most indeterminate in terms of prognosis.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Vol 29, Issue 17, p2391
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2010.32.6421