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- Title
Prognostic value of a combined estrogen receptor, progesterone receptor, Ki-67, and human epidermal growth factor receptor 2 immunohistochemical score and comparison with the Genomic Health recurrence score in early breast cancer.
- Authors
Cuzick, Jack; Dowsett, Mitch; Pineda, Silvia; Wale, Christopher; Salter, Janine; Quinn, Emma; Zabaglo, Lila; Mallon, Elizabeth; Green, Andrew R; Ellis, Ian O; Howell, Anthony; Buzdar, Aman U; Forbes, John F
- Abstract
We recently reported that the mRNA-based, 21-gene Genomic Health recurrence score (GHI-RS) provided additional prognostic information regarding distant recurrence beyond that obtained from classical clinicopathologic factors (age, nodal status, tumor size, grade, endocrine treatment) in women with early breast cancer, confirming earlier reports. The aim of this article is to determine how much of this information is contained in standard immunohistochemical (IHC) markers.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Vol 29, Issue 32, p4273
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2010.31.2835