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- Title
Randomized phase II trial of chemoradiotherapy followed by either dose-dense or metronomic temozolomide for newly diagnosed glioblastoma.
- Authors
Clarke, Jennifer L; Iwamoto, Fabio M; Sul, Joohee; Panageas, Katherine; Lassman, Andrew B; DeAngelis, Lisa M; Hormigo, Adília; Nolan, Craig P; Gavrilovic, Igor; Karimi, Sasan; Abrey, Lauren E
- Abstract
Alternative dosing schedules of temozolomide may improve survival in patients with newly diagnosed glioblastoma (GBM) by increasing the therapeutic index, overcoming common mechanisms of temozolomide resistance, or both. The goal of this randomized phase II study was to evaluate two different temozolomide regimens in the adjuvant treatment of newly diagnosed GBM.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Vol 27, Issue 23, p3861
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2008.20.7944