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- Title
Phase I dose escalation, pharmacokinetic and pharmacodynamic study of naptumomab estafenatox alone in patients with advanced cancer and with docetaxel in patients with advanced non-small-cell lung cancer.
- Authors
Borghaei, Hossein; Alpaugh, Katherine; Hedlund, Gunnar; Forsberg, Göran; Langer, Corey; Rogatko, Andre; Hawkins, Robert; Dueland, Svein; Lassen, Ulrik; Cohen, Roger B
- Abstract
Two phase I studies were conducted of ABR-217620 alone or in combination with docetaxel. This is a recombinant fusion protein consisting of a mutated variant of the superantigen staphylococcal enterotoxin E (SEA/E-120) linked to fragment antigen binding moiety of a monoclonal antibody recognizing the tumor-associated antigen 5T4.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Vol 27, Issue 25, p4116
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2008.20.2515