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- Title
Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group.
- Authors
Kunwar, Sandeep; Prados, Michael D; Chang, Susan M; Berger, Mitchel S; Lang, Frederick F; Piepmeier, Joseph M; Sampson, John H; Ram, Zvi; Gutin, Philip H; Gibbons, Robert D; Aldape, Kenneth D; Croteau, David J; Sherman, Jeffrey W; Puri, Raj K; Cintredekin Besudotox Intraparenchymal Study Group
- Abstract
Glioblastoma multiforme (GBM) is a devastating brain tumor with a median survival of 6 months after recurrence. Cintredekin besudotox (CB) is a recombinant protein consisting of interleukin-13 (IL-13) and a truncated form of Pseudomonas exotoxin (PE38QQR). Convection-enhanced delivery (CED) is a locoregional-administration method leading to high-tissue concentrations with large volume of distributions. We assessed the use of intracerebral CED to deliver CB in patients with recurrent malignant glioma (MG).
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Vol 25, Issue 7, p837
- ISSN
1527-7755
- Publication type
Journal Article
- DOI
10.1200/JCO.2006.08.1117