We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741.
- Authors
Citron, Marc L; Berry, Donald A; Cirrincione, Constance; Hudis, Clifford; Winer, Eric P; Gradishar, William J; Davidson, Nancy E; Martino, Silvana; Livingston, Robert; Ingle, James N; Perez, Edith A; Carpenter, John; Hurd, David; Holland, James F; Smith, Barbara L; Sartor, Carolyn I; Leung, Eleanor H; Abrams, Jeffrey; Schilsky, Richard L; Muss, Hyman B; Norton, Larry
- Abstract
Using a 2 x 2 factorial design, we studied the adjuvant chemotherapy of women with axillary node-positive breast cancer to compare sequential doxorubicin (A), paclitaxel (T), and cyclophosphamide (C) with concurrent doxorubicin and cyclophosphamide (AC) followed by paclitaxel (T) for disease-free (DFS) and overall survival (OS); to determine whether the dose density of the agents improves DFS and OS; and to compare toxicities.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Vol 21, Issue 8, p1431
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2003.09.081