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- Title
Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: results from two phase I studies.
- Authors
Morgan, Bruno; Thomas, Anne L; Drevs, Joachim; Hennig, Juergen; Buchert, Martin; Jivan, Asvina; Horsfield, Mark A; Mross, Klaus; Ball, Howard A; Lee, Lucy; Mietlowski, William; Fuxuis, Stefan; Unger, Clemens; O'Byrne, Ken; Henry, Andrew; Cherryman, Graham R; Laurent, Dirk; Dugan, Margaret; Marmé, Dieter; Steward, William P
- Abstract
PTK787/ZK 222584 (PTK/ZK), an orally active inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases, inhibits VEGF-mediated angiogenesis. The pharmacodynamic effects of PTK/ZK were evaluated by assessing changes in contrast-enhancement parameters of metastatic liver lesions using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with advanced colorectal cancer treated in two ongoing, dose-escalating phase I studies.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Vol 21, Issue 21, p3955
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2003.08.092