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- Title
MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families.
- Authors
Vasen, H F; Stormorken, A; Menko, F H; Nagengast, F M; Kleibeuker, J H; Griffioen, G; Taal, B G; Moller, P; Wijnen, J T
- Abstract
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disease characterized by the clustering of colorectal cancer, endometrial cancer, and various other cancers. The disease is caused by mutations in DNA-mismatch-repair (MMR) genes, most frequently in MLH1, MSH2, and MSH6. The aims of the present study were to compare the risk of developing colorectal, endometrial, and other cancers between families with the various MMR-gene mutations.
- Publication
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Vol 19, Issue 20, p4074
- ISSN
0732-183X
- Publication type
Journal Article
- DOI
10.1200/JCO.2001.19.20.4074