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- Title
Conserved epitopes in the protein tyrosine phosphatase family of diabetes autoantigens.
- Authors
Liu, Y; Wenzlau, J M; Yu, L; Patel, C; Eisenbarth, G S; Hutton, J C; Davidson, H W
- Abstract
IA2 and phogrin are important targets of humoral and cell-mediated autoimmunity in type 1 diabetes in man. They belong to a conserved subfamily of transmembrane protein tyrosine phosphatases (PTPs) associated with the regulatory pathway of secretion. To examine potential cross-reactivity between PTP family members we tested sera from T1D patients for reactivity to IA2, and the Drosophila (FLYDA) and C. elegans (IDA) orthologs using radioimmunoprecipitation assays of (35)S Met-labeled in vitro translated products of the cytosolic domains of these proteins. Approximately 80% of sera reacted with at least one probe. Of these, 82.5% showed reactivity to human IA2, 74.1% to FLYDA, and 33.7% to IDA. The majority of sera that bound FLYDA and/or IDA also recognized IA2. This raises the possibility that in some cases reactivity to IA2 may have arisen by molecular mimicry.
- Publication
Annals of the New York Academy of Sciences, 2008, Vol 1150, p245
- ISSN
1749-6632
- Publication type
Journal Article
- DOI
10.1196/annals.1447.035