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- Title
Role of autophagy during methamphetamine neurotoxicity.
- Authors
Pasquali, Livia; Lazzeri, Gloria; Isidoro, Ciro; Ruggieri, Stefano; Paparelli, Antonio; Fornai, Francesco
- Abstract
Methamphetamine causes nigrostriatal denervation and striatal dopamine loss, while sparing nigral cell bodies. Nigral dopamine neurons feature autophagic vacuoles and cytoplasmic alpha-synuclein-, ubiquitin- and parkin-positive inclusion-like bodies. On that basis, autophagy was considered essential in methamphetamine-induced neurotoxicity, but its neurotoxic or protective role has never been addressed. Here we review the gap between the descriptive evidence on activation of autophagy and the lack of knowledge about its role during methamphetamine intoxication. Our preliminary findings rule out a detrimental role for autophagy; this represents the first step in understanding the consequence of activation of autophagy in methamphetamine toxicity.
- Publication
Annals of the New York Academy of Sciences, 2008, Vol 1139, p191
- ISSN
1749-6632
- Publication type
Journal Article
- DOI
10.1196/annals.1432.016