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- Title
Autoimmune oophoritis in the adolescent.
- Authors
Welt, Corrine K
- Abstract
Autoimmune oophoritis presents in adolescents as a component of autoimmune polyendocrine syndrome type I or type II. Autoimmune oophoritis can be diagnosed in women with primary ovarian insufficiency in the presence of adrenal cortical or steroid cell antibodies, and/or antibodies to adrenal and ovarian steroidogenic enzymes. The ovaries are cystic macroscopically, with a lymphocytic infiltrate in the steroidogenic theca cells. The immune infiltrate results in low estradiol levels and a compensatory increase in FSH levels. Granulosa cells are spared, and inhibin A and B levels are normal to high. Treatment is aimed at symptom relief with further investigation needed to assess treatment options such as immunosuppression.
- Publication
Annals of the New York Academy of Sciences, 2008, Vol 1135, p118
- ISSN
0077-8923
- Publication type
Journal Article
- DOI
10.1196/annals.1429.006