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- Title
Role of Toll-like receptors in HMGB1 release from macrophages.
- Authors
Pisetsky, David S; Jiang, Weiwen
- Abstract
HMGB1 is a nonhistone nuclear protein that can serve as a cytokine and activate innate immunity. The translocation of this molecule from the inside to the outside of cells is a critical event in inflammation, occurring following activation of certain Toll-like receptors (TLRs) as well as during the course of apoptotic as well as necrotic cell death. Because the kinetics of HMGB1 release differs from that of a conventional cytokine, it provides a broader therapeutic window and may be an important new target of therapy for inflammatory, autoimmune, and infectious diseases.
- Publication
Annals of the New York Academy of Sciences, 2007, Vol 1109, p58
- ISSN
0077-8923
- Publication type
Journal Article
- DOI
10.1196/annals.1398.008