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- Title
The Role of Selenite on Microglial Migration.
- Authors
PUPPA, LISA DALLA; SAVASKAN, NICOLAI E.; BRÄUER, ANJA U.; BEHNE, DIETRICH; KYRIAKOPOULOS, ANTONIOS
- Abstract
Oxidative brain damage, such as excitotoxicity and stroke, leads to primary neuronal destruction. The primary damage is further potentiated by macrophages and microglial cells, which are attracted and invade into the zone of damage resulting in secondary neuronal death. Since the essential trace element selenium has anti-inflammatory properties, we analyzed the effects of selenium on these inflammatory cells. Here, we show that the essential trace element selenium abrogates the stress-induced migration of microglial cells. Thus, the antimigratory effects of selenium may attenuate the secondary cell death cascade by preventing microglial invasion.
- Publication
Annals of the New York Academy of Sciences, 2007, Vol 1096, p179
- ISSN
0077-8923
- Publication type
Academic Journal
- DOI
10.1196/annals.1397.084