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- Title
Epigenetic control of hematopoietic stem cell aging the case of Ezh2.
- Authors
De Haan, Gerald; Gerrits, Alice
- Abstract
Hematopoietic stem cells have potent, but not unlimited, selfrenewal potential. The mechanisms that restrict selfrenewal are likely to play a role during aging. Recent data suggest that the regulation of histone modifications by Polycomb group genes may be of crucial relevance to balance selfrenewal and aging. We provide evidence for the involvement of one of these Polycomb group genes, Ezh2, in aging of the hematopoietic stem cell system.
- Publication
Annals of the New York Academy of Sciences, 2007, Vol 1106, p233
- ISSN
0077-8923
- Publication type
Journal Article
- DOI
10.1196/annals.1392.008