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- Title
[<sup>123</sup>I]5-IA-85380 SPECT Imaging of β<sub>2</sub>-Nicotinic Acetylcholine Receptor Availability in the Aging Human Brain.
- Authors
MITSIS, EFFIE M.; COSGROVE, KELLY P.; STALEY, JULIE K.; FROHLICH, ERIN B.; BOIS, FREDERIC; TAMAGNAN, GILLES D.; ESTOK, KRISTINA M.; SEIBYL, JOHN P.; VAN DYCK, CHRISTOPHER H.
- Abstract
Human postmortem studies have reported decreases with age in high-affinity nicotine binding in brain. We have been investigating in vivo the availability of the β2-containing nicotinic acetylcholine receptor (β2-nAChR) in healthy nonsmokers (18–85 years of age) using [123I]5-IA-85380 SPECT imaging. Age and regional β2-nAChR availability (VT,) have been observed to be inversely correlated in all brain regions analyzed, with decline ranging from 21% (cerebellum) to 36% (thalamus), or by up to 5% per decade of life. Preliminary results have confirmed postmortem reports of age-related decline in high-affinity nicotine binding with age and may elucidate the role of β2-nAChRs in the cognitive decline associated with aging.
- Publication
Annals of the New York Academy of Sciences, 2007, Vol 1097, p168
- ISSN
0077-8923
- Publication type
Academic Journal
- DOI
10.1196/annals.1379.015