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- Title
TEDDY--The Environmental Determinants of Diabetes in the Young: an observational clinical trial.
- Authors
Hagopian, William A; Lernmark, Ake; Rewers, Marian J; Simell, Olli G; She, Jin-Xiong; Ziegler, Anette G; Krischer, Jeffrey P; Akolkar, Beena
- Abstract
The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.
- Publication
Annals of the New York Academy of Sciences, 2006, Vol 1079, p320
- ISSN
0077-8923
- Publication type
Journal Article
- DOI
10.1196/annals.1375.049