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- Title
Pancreatic autoimmunity induction with insulin B:9-23 peptide and viral mimics in the NZB mouse.
- Authors
Devendra, Devasenan; Miao, Dongmei; Nakayama, Maki; Eisenbarth, George S; Liu, Edwin
- Abstract
To create a new experimental model of diabetes, we used the New Zealand Black (NZB) mouse as a potential model. NZB mice were immunized with B:9-23 insulin peptide in IFA and the viral mimic, poly(A:U). No diabetes was observed but blood glucose was significantly higher in the B:9-23 peptide group compared to controls. Insulin autoantibodies (IAA) were only induced in groups given the B:9-23 peptide. B:9-23 alone induced peri-insulitis. We demonstrate insulin autoimmunity in the NZB mouse using the insulin peptide B:9-23 and viral mimics. The reason for the protection from diabetes despite the presence of autoimmunity is currently not established.
- Publication
Annals of the New York Academy of Sciences, 2006, Vol 1079, p135
- ISSN
0077-8923
- Publication type
Journal Article
- DOI
10.1196/annals.1375.020