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- Title
Interleukin-6: a cytokine and/or a major modulator of the response to somatic stress.
- Authors
Mastorakos, George; Ilias, Ioannis
- Abstract
The hypothalamic-pituitary-adrenal (HPA) axis and the proinflammatory cytokines (and interleukin-6 [IL-6] in particular) are enmeshed in the response to somatic stress, either in health or in acute or chronic disease. Usually IL-6 is elevated in states of septic (such as sepsis) or aseptic inflammation (such as rheumatoid arthritis). Exercise is a form of somatic stress. Local tissue IL-6 elevation is noted during shorter and less intense exercise, whereas brief peripheral IL-6 "bursts" are observed with longer and more intense exercise. Therapeutic interventions that target IL-6 or its soluble receptor are currently assessed, with an emphasis on autoimmune diseases and inflammatory conditions.
- Publication
Annals of the New York Academy of Sciences, 2006, Vol 1088, p373
- ISSN
0077-8923
- Publication type
Journal Article
- DOI
10.1196/annals.1366.021