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- Title
Prevention of accelerated cell aging in the Werner syndrome.
- Authors
Davis, Terence; Haughton, Michèle F; Jones, Christopher J; Kipling, David
- Abstract
In the Werner syndrome (WS) fibroblasts have an increased life span and growth rate when treated with the p38 inhibitor SB203580. Additionally, the cellular morphology reverts to that seen in young normal fibroblasts. The p38 pathway is activated in young WS cells, associated with high levels of p21(WAF1) leading to cell cycle arrest, and is suppressed by SB203580. As these changes are also seen in telomerized WS cells, these data show that the growth problems seen in WS cells, and perhaps the accelerated in vivo aging, are due to a telomere-independent premature senescence mechanism. The suppression of this mechanism by SB203580 treatment suggests a route whereby WS may be amenable to therapeutic intervention.
- Publication
Annals of the New York Academy of Sciences, 2006, Vol 1067, p243
- ISSN
0077-8923
- Publication type
Journal Article
- DOI
10.1196/annals.1354.031