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- Title
Autologous stem cell transplantation as rescue therapy in malignant forms of multiple sclerosis.
- Authors
Mancardi, Giovanni Luigi; Murialdo, Alessandra; Rossi, Paolo; Gualandi, Francesca; Martino, Gianvito; Marmont, Alberto; Ciceri, Fabio; Schenone, Angelo; Parodi, Roberto Carlo; Capello, Elisabetta; Comi, Giancarlo; Uccelli, Antonio
- Abstract
Malignant forms of multiple sclerosis (MS) represent a limited group of very aggressive demyelinating diseases, which rapidly progress to severe disability leading often to life-threatening conditions. On these clinical entities, currently available therapies for MS are not very effective. Recently, it has been demonstrated that intense immunosuppression followed by autologous stem cell transplantation (ASCT) can affect the clinical course of individuals with severe MS and completely abrogate the inflammatory activity detected by magnetic resonance imaging (MRI). We report on the treatment with intense immune ablation followed by ASCT of three patients with malignant MS whose clinical course indicated a dramatically poor prognosis. This procedure succeeded in halting the rapidly worsening course of disease. The effect was long lasting, as demonstrated by a sustained efficacy over a two-year period in two subjects and 12 months in the third case. In addition, a striking effect on inflammation-related MRI findings was obtained. These results support a role for intense immunosuppression followed by ASCT as treatment in rapidly evolving malignant MS cases unresponsive to conventional therapies.
- Publication
Multiple sclerosis (Houndmills, Basingstoke, England), 2005, Vol 11, Issue 3, p367
- ISSN
1352-4585
- Publication type
Journal Article
- DOI
10.1191/1352458505ms1181cr