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- Title
High sensitivity, specificity and predictive value of the Connective Tissue Disease Screening Questionnaire among urban African-American women.
- Authors
Karlson, E W; Costenbader, K H; McAlindon, T E; Massarotti, E M; Fitzgerald, L M; Jajoo, R; Husni, E; Wright, E A; Pankey, H; Fraser, P A
- Abstract
The Connective Tissue Disease Screening Questionnaire (CSQ), developed to screen populations for SLE and other CTDs, has been validated in a predominantly Caucasian population with hospital-based controls. We aimed to test the performance characteristics of the CSQ in an urban, predominantly African-American population. The CSQ was administered by interview to women recruited for a study of environmental risk factors and SLE, including 99 cases with SLE validated by medical record review and 202 healthy controls recruited from the community. Overall, 88% of subjects had African heritage, 6% were Hispanic and 4% were non-Hispanic Caucasian. Controls were more likely to report African heritage than cases (91% versus 82%, P = 0.001). Sensitivity for detecting SLE was 88% and specificity was 91%. In this study, where the prevalence of SLE was 33%, predictive value of a positive CSQ was 82% and predictive value of a negative CSQ was 94%. The CSQ has slightly lower sensitivity but greater specificity for SLE in an urban, predominantly African-American population with community-based controls compared with a Caucasian population with hospital-based controls. These results suggest that the CSQ has adequate sensitivity and specificity and could be used in population studies to screen African-American women for SLE.
- Publication
Lupus, 2005, Vol 14, Issue 10, p832
- ISSN
0961-2033
- Publication type
Journal Article
- DOI
10.1191/0961203305lu2227oa