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Title
Insulators as mediators of intra- and inter-chromosomal interactions: a common evolutionary theme.
Authors
Ong, Chin-Tong; Corces, Victor G
Abstract
Insulator elements mediate intra- and inter-chromosomal interactions. The insulator protein CCCTC-binding factor (CTCF) is important for insulator function in several animals but a report in BMC Molecular Biology shows that Caenorhabditis elegans, yeast and plants lack CTCF. Alternative proteins may have a similar function in these organisms.