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- Title
The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal.
- Authors
Böse, Jens; Gruber, Achim D; Helming, Laura; Schiebe, Stefanie; Wegener, Ivonne; Hafner, Martin; Beales, Marianne; Köntgen, Frank; Lengeling, Andreas
- Abstract
Phagocytosis of apoptotic cells is fundamental to animal development, immune function and cellular homeostasis. The phosphatidylserine receptor (Ptdsr) on phagocytes has been implicated in the recognition and engulfment of apoptotic cells and in anti-inflammatory signaling. To determine the biological function of the phosphatidylserine receptor in vivo, we inactivated the Ptdsr gene in the mouse.
- Publication
Journal of biology, 2004, Vol 3, Issue 4, p15
- ISSN
1475-4924
- Publication type
Journal Article
- DOI
10.1186/jbiol10