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- Title
Tranexamic acid: less bleeding and less thrombosis?
- Authors
Godier, Anne; Roberts, Ian; Hunt, Beverley J
- Abstract
The early administration of tranexamic acid (TXA) to bleeding trauma patients reduces all-cause mortality without increasing the risk of vascular occlusive events. Indeed, the risk of arterial thrombosis appears to be reduced with TXA. In this commentary we hypothesize that TXA has an antithrombotic effect and explore potential mechanisms. These include inhibition of the inflammatory effects of plasmin, effects on platelets and effects on factors V and VIII. If proven, these antithrombotic effects would have major implications for the systemic use of TXA in surgical patients, where TXA has been clearly shown to reduce bleeding.
- Publication
Critical care (London, England), 2012, Vol 16, Issue 3, p135
- ISSN
1466-609X
- Publication type
Journal Article
- DOI
10.1186/cc11374