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- Title
Early use of imipenem/cilastatin and vancomycin followed by de-escalation versus conventional antimicrobials without de-escalation for patients with hospital-acquired pneumonia in a medical ICU: a randomized clinical trial.
- Abstract
The article presents a study that investigated the effects of early use of broad-spectrum antimicrobials in critically ill patients with hospital-acquired pneumonia (HAP). In the study, between November 2004 and October 2006, 109 MICU patients with HAP were enrolled. Initial antimicrobial adequacy was significantly higher in the de-escalation (DE) han in the NDE group for Gram-positive organisms, but not for Gram-negative organisms.
- Publication
Critical Care, 2012, Vol 16, Issue 1, pR28
- ISSN
1364-8535
- Publication type
Academic Journal
- DOI
10.1186/cc11197