We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation.
- Authors
Fox, Emily M; Kuba, María Gabriela; Miller, Todd W; Davies, Barry R; Arteaga, Carlos L
- Abstract
Estrogen receptor α-positive (ER+) breast cancers adapt to hormone deprivation and acquire resistance to antiestrogen therapies. Upon acquisition of hormone independence, ER+ breast cancer cells increase their dependence on the phosphatidylinositol-3 kinase (PI3K)/AKT pathway. We examined the effects of AKT inhibition and its compensatory upregulation of insulin-like growth factor (IGF)-I/InsR signaling in ER+ breast cancer cells with acquired resistance to estrogen deprivation.
- Publication
Breast cancer research : BCR, 2013, Vol 15, Issue 4, pR55
- ISSN
1465-542X
- Publication type
Journal Article
- DOI
10.1186/bcr3449