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- Title
Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer.
- Authors
Meric-Bernstam, Funda; Chen, Huiqin; Akcakanat, Argun; Do, Kim-Anh; Lluch, Ana; Hennessy, Bryan T; Hortobagyi, Gabriel N; Mills, Gordon B; Gonzalez-Angulo, Ana
- Abstract
Translation initiation is activated in cancer through increase in eukaryotic initiation factor 4E (eIF4E), eIF4G, phosphorylated eIF4E-binding protein (p4E-BP1) and phosphorylated ribosomal protein S6 (pS6), and decreased programmed cell death protein 4 (pdcd4), a translational inhibitor. Further, translation elongation is deregulated though alterations in eukaryotic elongation factor 2 (eEF2) and eEF2 kinase (eEF2K). We sought to determine the association of these translational aberrations with clinical-pathologic factors and survival outcomes in hormone receptor-positive breast cancer.
- Publication
Breast cancer research : BCR, 2012, Vol 14, Issue 5, pR138
- ISSN
1465-542X
- Publication type
Journal Article
- DOI
10.1186/bcr3343