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- Title
Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes.
- Authors
Peck, Amy R; Witkiewicz, Agnieszka K; Liu, Chengbao; Klimowicz, Alexander C; Stringer, Ginger A; Pequignot, Edward; Freydin, Boris; Yang, Ning; Ertel, Adam; Tran, Thai H; Girondo, Melanie A; Rosenberg, Anne L; Hooke, Jeffrey A; Kovatich, Albert J; Shriver, Craig D; Rimm, David L; Magliocco, Anthony M; Hyslop, Terry; Rui, Hallgeir
- Abstract
Signal transducer and activator of transcripton-5a (Stat5a) and its close homologue, Stat5b, mediate key physiological effects of prolactin and growth hormone in mammary glands. In breast cancer, loss of nuclear localized and tyrosine phosphorylated Stat5a/b is associated with poor prognosis and increased risk of antiestrogen therapy failure. Here we quantify for the first time levels of Stat5a and Stat5b over breast cancer progression, and explore their potential association with clinical outcome.
- Publication
Breast cancer research : BCR, 2012, Vol 14, Issue 5, pR130
- ISSN
1465-542X
- Publication type
Journal Article
- DOI
10.1186/bcr3328