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- Title
17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration.
- Authors
Aka, Juliette A; Zerradi, Mouna; Houle, François; Huot, Jacques; Lin, Sheng-Xiang
- Abstract
Human 17beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a steroid-converting enzyme that has long been known to play critical roles in estradiol synthesis and more recently in dihydrotestosterone (DHT) inactivation, showing a dual function that promotes breast cancer cell proliferation. Previously, we reported the first observation of the influence of the enzyme on endogenous estrogen-responsive gene expression. Here, we demonstrate the impact of 17β-HSD1 expression on the breast cancer cell proteome and investigate its role in cell migration.
- Publication
Breast cancer research : BCR, 2012, Vol 14, Issue 3, pR92
- ISSN
1465-542X
- Publication type
Journal Article
- DOI
10.1186/bcr3207