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- Title
Estrogen-related receptor alpha: an orphan finds a family.
- Authors
Ochnik, Aleksandra M; Yee, Douglas
- Abstract
Identification of molecules and their effectors has led to new therapies designed to specifically inhibit pathways in molecularly defined breast cancer subtypes. An orphan nuclear receptor, estrogen-related receptor alpha, has been shown to be a downstream target of two tyrosine kinase growth factor receptors: human epidermal growth factor receptor 2 and the type I insulin-like growth factor receptor. Identifying the mechanistic actions of orphan nuclear receptors could lead to new biomarkers and molecular targets in malignancy.
- Publication
Breast cancer research : BCR, 2012, Vol 14, Issue 3, p309
- ISSN
1465-542X
- Publication type
Journal Article
- DOI
10.1186/bcr3124