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- Title
Lack of EGFR-activating mutations in European patients with triple-negative breast cancer could emphasise geographic and ethnic variations in breast cancer mutation profiles.
- Authors
Jacot, William; Lopez-Crapez, Evelyne; Thezenas, Simon; Senal, Romain; Fina, Frédéric; Bibeau, Frédéric; Romieu, Gilles; Lamy, Pierre-Jean
- Abstract
Triple-negative breast cancers (TNBCs) are characterised by lack of expression of hormone receptors and epidermal growth factor receptor 2 (HER-2). As they frequently express epidermal growth factor receptors (EGFRs), anti-EGFR therapies are currently assessed for this breast cancer subtype as an alternative to treatments that target HER-2 or hormone receptors. Recently, EGFR-activating mutations have been reported in TNBC specimens in an East Asian population. Because variations in the frequency of EGFR-activating mutations in East Asians and other patients with lung cancer have been described, we evaluated the EGFR mutational profile in tumour samples from European patients with TNBC.
- Publication
Breast cancer research : BCR, 2011, Vol 13, Issue 6, pR133
- ISSN
1465-542X
- Publication type
Journal Article
- DOI
10.1186/bcr3079