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- Title
Trastuzumab-DM1 causes tumour growth inhibition by mitotic catastrophe in trastuzumab-resistant breast cancer cells in vivo.
- Authors
Barok, Mark; Tanner, Minna; Köninki, Katri; Isola, Jorma
- Abstract
Trastuzumab is widely used for the treatment of HER2-positive breast cancer. Despite encouraging clinical results, a significant fraction of patients are, or become, refractory to the drug. To overcome this, trastuzumab-DM1 (T-DM1), a newer, more potent drug has been introduced. We tested the efficacy and mechanisms of action of T-DM1 in nine HER2-positive breast cancer cell lines in vitro and in vivo. The nine cell lines studied included UACC-893, MDA-453 and JIMT-1, which are resistant to both trastuzumab and lapatinib.
- Publication
Breast cancer research : BCR, 2011, Vol 13, Issue 2, pR46
- ISSN
1465-542X
- Publication type
Journal Article
- DOI
10.1186/bcr2868