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- Title
High serum sCD163/sTWEAK ratio is associated with lower risk of digital ulcers but more severe skin disease in patients with systemic sclerosis.
- Authors
Kowal-Bielecka, Otylia; Bielecki, Marek; Guiducci, Serena; Trzcinska-Butkiewicz, Beata; Michalska-Jakubus, Małgorzata; Matucci-Cerinic, Marco; Brzosko, Marek; Krasowska, Dorota; Chyczewski, Lech; Kowal, Krzysztof
- Abstract
Systemic sclerosis (SSc) is an autoimmune disease characterized by chronic inflammation, vascular injury and excessive fibrosis. CD163 is a scavenger receptor which affects inflammatory response and may contribute to connective tissue remodelling. It has recently been demonstrated that CD163 can bind and neutralize the TNF-like weak inducer of apoptosis (TWEAK), a multifunctional cytokine which regulates inflammation, angiogenesis and tissue remodelling. We aimed to investigate the relationships between serum levels of soluble CD163 (sCD163) and soluble TWEAK (sTWEAK) in relation to disease manifestations in SSc patients.
- Publication
Arthritis research & therapy, 2013, Vol 15, Issue 3, pR69
- ISSN
1478-6362
- Publication type
Journal Article
- DOI
10.1186/ar4246