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- Title
Monocyte populations as markers of response to adalimumab plus MTX in rheumatoid arthritis.
- Authors
Chara, Luis; Sánchez-Atrio, Ana; Pérez, Ana; Cuende, Eduardo; Albarrán, Fernando; Turrión, Ana; Chevarria, Julio; Sánchez, Miguel A; Monserrat, Jorge; de la Hera, Antonio; Prieto, Alfredo; Sanz, Ignacio; Diaz, David; Alvarez-Mon, Melchor
- Abstract
The treatment of rheumatoid arthritis (RA) patients with anti-tumor necrosis factor alpha (TNFα) biological drugs has dramatically improved the prognosis of these patients. However, a third of the treated patients do not respond to this therapy. Thus, the search for biomarkers of clinical response to these agents is currently highly active. Our aim is to analyze the number and distribution of circulating monocytes, and of their CD14⁺highCD16⁻, CD14⁺highCD16⁺ and CD14⁺lowCD16+ subsets in methotrexate (MTX) non-responder patients with RA, and to determine their value in predicting the clinical response to adalimumab plus MTX treatment.
- Publication
Arthritis research & therapy, 2012, Vol 14, Issue 4, pR175
- ISSN
1478-6362
- Publication type
Journal Article
- DOI
10.1186/ar3928