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- Title
Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells.
- Authors
Steinert, Andre F; Weissenberger, Manuel; Kunz, Manuela; Gilbert, Fabian; Ghivizzani, Steven C; Göbel, Sascha; Jakob, Franz; Nöth, Ulrich; Rudert, Maximilian
- Abstract
To date, no single most-appropriate factor or delivery method has been identified for the purpose of mesenchymal stem cell (MSC)-based treatment of cartilage injury. Therefore, in this study we tested whether gene delivery of the growth factor Indian hedgehog (IHH) was able to induce chondrogenesis in human primary MSCs, and whether it was possible by such an approach to modulate the appearance of chondrogenic hypertrophy in pellet cultures in vitro.
- Publication
Arthritis research & therapy, 2012, Vol 14, Issue 4, pR168
- ISSN
1478-6362
- Publication type
Journal Article
- DOI
10.1186/ar3921