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- Title
RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis.
- Authors
Martínez-Calatrava, Maria J; Prieto-Potín, Ivan; Roman-Blas, Jorge A; Tardio, Lidia; Largo, Raquel; Herrero-Beaumont, Gabriel
- Abstract
The receptor activator nuclear factor-kappaB ligand (RANKL) diffuses from articular cartilage to subchondral bone. However, the role of chondrocyte-synthesized RANKL in rheumatoid arthritis-associated juxta-articular bone loss has not yet been explored. This study aimed to determine whether RANKL produced by chondrocytes induces osteoclastogenesis and juxta-articular bone loss associated with chronic arthritis.
- Publication
Arthritis research & therapy, 2012, Vol 14, Issue 3, pR149
- ISSN
1478-6362
- Publication type
Journal Article
- DOI
10.1186/ar3884