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- Title
CD109, a TGF-β co-receptor, attenuates extracellular matrix production in scleroderma skin fibroblasts.
- Authors
Man, Xiao-Yong; Finnson, Kenneth W; Baron, Murray; Philip, Anie
- Abstract
Scleroderma or systemic sclerosis (SSc) is a complex connective tissue disease characterized by fibrosis of skin and internal organs. Transforming growth factor beta (TGF-β) plays a key role in the pathogenesis of SSc fibrosis. We have previously identified CD109 as a novel TGF-β co-receptor that inhibits TGF-β signaling. The aim of the present study was to determine the role of CD109 in regulating extracellular matrix (ECM) production in human SSc skin fibroblasts.
- Publication
Arthritis research & therapy, 2012, Vol 14, Issue 3, pR144
- ISSN
1478-6362
- Publication type
Journal Article
- DOI
10.1186/ar3877