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- Title
Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies.
- Authors
Liu, Chih Long; Tangsombatvisit, Stephanie; Rosenberg, Jacob M; Mandelbaum, Gil; Gillespie, Emily C; Gozani, Or P; Alizadeh, Ash A; Utz, Paul J
- Abstract
Autoreactivity to histones is a pervasive feature of several human autoimmune disorders, including systemic lupus erythematosus (SLE). Specific post-translational modifications (PTMs) of histones within neutrophil extracellular traps (NETs) may potentially drive the process by which tolerance to these chromatin-associated proteins is broken. We hypothesized that NETs and their unique histone PTMs might be capable of inducing autoantibodies that target histones.
- Publication
Arthritis research & therapy, 2012, Vol 14, Issue 1, pR25
- ISSN
1478-6362
- Publication type
Journal Article
- DOI
10.1186/ar3707