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- Title
Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes.
- Authors
Akhtar, Nahid; Haqqi, Tariq M
- Abstract
Epigallocatechin-3-gallate (EGCG) is a bioactive polyphenol of green tea and exerts potent anti-inflammatory effects by inhibiting signaling events and gene expression. Interleukin-1beta (IL-1β) is the principal cytokine linked to cartilage degradation in osteoarthritis (OA). The objective of this study was to evaluate the global effect of EGCG on IL-1β-induced expression of proteins associated with OA pathogenesis in human chondrocytes.
- Publication
Arthritis research & therapy, 2011, Vol 13, Issue 3, pR93
- ISSN
1478-6362
- Publication type
Journal Article
- DOI
10.1186/ar3368