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- Title
Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis.
- Authors
Wu, Jun; Ekman, Carl; Jönsen, Andreas; Sturfelt, Gunnar; Bengtsson, Anders A; Gottsäter, Anders; Lindblad, Bengt; Lindqvist, Elisabet; Saxne, Tore; Dahlbäck, Björn
- Abstract
Mer and Tyro3 are receptor tyrosine kinases important for the phagocytosis of apoptotic cells. Together with Axl, they constitute the TAM receptor family. These receptors can be shed from the cell membrane and their soluble extracellular regions can be found in plasma. The objective of this study was to elucidate whether the plasma levels of soluble Mer (sMer) and Tyro3 (sTyro3) were increased in systemic lupus erythematosis (SLE), rheumatoid arthritis (RA), or critical limb ischemia (CLI).
- Publication
Arthritis research & therapy, 2011, Vol 13, Issue 2, pR62
- ISSN
1478-6362
- Publication type
Journal Article
- DOI
10.1186/ar3316