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- Title
TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis.
- Authors
Dharmapatni, Anak A S S K; Smith, Malcolm D; Crotti, Tania N; Holding, Christopher A; Vincent, Cristina; Weedon, Helen M; Zannettino, Andrew C W; Zheng, Timothy S; Findlay, David M; Atkins, Gerald J; Haynes, David R
- Abstract
TNF-like weak inducer of apoptosis (TWEAK) has been proposed as a mediator of inflammation and bone erosion in rheumatoid arthritis (RA). This study aimed to investigate TWEAK and TWEAK receptor (Fn14) expression in synovial tissue from patients with active and inactive rheumatoid arthritis (RA), osteoarthritis (OA) and normal controls and assess soluble (s)TWEAK levels in the synovial fluids from patients with active RA and OA. Effects of sTWEAK on osteoclasts and osteoblasts were investigated in vitro.
- Publication
Arthritis research & therapy, 2011, Vol 13, Issue 2, pR51
- ISSN
1478-6362
- Publication type
Journal Article
- DOI
10.1186/ar3294