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- Title
TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study.
- Authors
Kawasaki, Aya; Furukawa, Hiroshi; Kondo, Yuya; Ito, Satoshi; Hayashi, Taichi; Kusaoi, Makio; Matsumoto, Isao; Tohma, Shigeto; Takasaki, Yoshinari; Hashimoto, Hiroshi; Sumida, Takayuki; Tsuchiya, Naoyuki
- Abstract
The Toll-like receptor 7 (TLR7) gene, encoded on human chromosome Xp22.3, is crucial for type I interferon production. A recent multicenter study in East Asian populations, comprising Chinese, Korean and Japanese participants, identified an association of a TLR7 single-nucleotide polymorphism (SNP) located in the 3' untranslated region (3' UTR), rs3853839, with systemic lupus erythematosus (SLE), especially in males, although some difference was observed among the tested populations. To test whether additional polymorphisms contribute to SLE in Japanese, we systematically analyzed the association of TLR7 with SLE in a Japanese female population.
- Publication
Arthritis research & therapy, 2011, Vol 13, Issue 2, pR41
- ISSN
1478-6362
- Publication type
Journal Article
- DOI
10.1186/ar3277