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- Title
Effects of atorvastatin on plasma matrix metalloproteinase-9 concentration after glial tumor resection; a randomized, double blind, placebo controlled trial.
- Authors
Mohebbi, Niayesh; Khoshnevisan, Alireza; Naderi, Soheil; Abdollahzade, Sina; Salamzadeh, Jamshid; Javadi, Mohammadreza; Mojtahedzadeh, Mojtaba; Gholami, Kheirollah
- Abstract
Neurosurgical procedures such as craniotomy and brain tumor resection could potentially lead to unavoidable cerebral injuries. Matrix metalloproteinase-9 (MMP-9) is up-regulated in neurological injuries. Statins have been suggested to reduce MMP- 9 level and lead to neuroprotection. Atorvastatin preoperatively administered to evaluate its neuroprotective effects and outcome assessment in neurosurgical-induced brain injuries after glial tumor resection. In this prospective, randomized, double-blind, placebo-controlled trial, 42 patients undergoing glial tumor surgery randomly received 40 mg atorvastatin or placebo twice daily from seven days prior to operation and continued for a 3 weeks period. Plasma MMP-9 concentration measured 4 times, immediately before starting atorvastatin or placebo, immediately before surgery, 24 hours and two weeks after the surgery. Karnofsky performance score was assessed before first dose of atorvastatin as a baseline and 2 months after the surgery.
- Publication
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2014, Vol 22, Issue 1, p10
- ISSN
1560-8115
- Publication type
Journal Article
- DOI
10.1186/2008-2231-22-10