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- Title
Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2.
- Authors
Schultz, Nikolaus; Marenstein, Dina R; De Angelis, Dino A; Wang, Wei-Qing; Nelander, Sven; Jacobsen, Anders; Marks, Debora S; Massagué, Joan; Sander, Chris
- Abstract
RNA interference (RNAi) screens have been used to identify novel components of signal-transduction pathways in a variety of organisms. We performed a small interfering (si)RNA screen for novel members of the transforming growth factor (TGF)-β pathway in a human keratinocyte cell line. The TGF-β pathway is integral to mammalian cell proliferation and survival, and aberrant TGF-β responses have been strongly implicated in cancer.
- Publication
Silence, 2011, Vol 2, p3
- ISSN
1758-907X
- Publication type
Journal Article
- DOI
10.1186/1758-907X-2-3