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- Title
Reducing ligation bias of small RNAs in libraries for next generation sequencing.
- Authors
Sorefan, Karim; Pais, Helio; Hall, Adam E; Kozomara, Ana; Griffiths-Jones, Sam; Moulton, Vincent; Dalmay, Tamas
- Abstract
The use of nucleic acid-modifying enzymes has driven the rapid advancement in molecular biology. Understanding their function is important for modifying or improving their activity. However, functional analysis usually relies upon low-throughput experiments. Here we present a method for functional analysis of nucleic acid-modifying enzymes using next generation sequencing.
- Publication
Silence, 2012, Vol 3, Issue 1, p4
- ISSN
1758-907X
- Publication type
Journal Article
- DOI
10.1186/1758-907X-3-4