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- Title
Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody.
- Abstract
The article offers information on the study conducted by the authors related to uterine and ovarian carcinosarcomas overexpressing human trophoblastic cell-surface marker (Trop-2) that are sensitive to hRS7, a humanized anti-Trop-2 antibody. It states that evaluated the expression of Trop-2 and the potential of hRS7 a humanized monoclonal anti-Trop-2 antibody as a therapeutic strategy against treatment-refractory human uterine (UMMT) and ovarian (OMMT) carcinosarcoma cell lines. It mentions that Trop-2 expression was evaluated by immunohistochemistry (IHC) in paraffin-embedded tumor tissues, by real-time polymerase-chain-reaction (RT-PCR) and flow-cytometry in cell lines.
- Publication
Journal of Experimental & Clinical Cancer Research (17569966), 2011, Vol 30, Issue 1, p106
- ISSN
1756-9966
- Publication type
Academic Journal
- DOI
10.1186/1756-9966-30-106