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- Title
p38 mitogen-activated protein kinase and mitogen-activated protein kinase-activated protein kinase 2 (MK2) signaling in atrophic and hypertrophic denervated mouse skeletal muscle.
- Authors
Evertsson, Kim; Fjällström, Ann-Kristin; Norrby, Marlene; Tågerud, Sven
- Abstract
p38 mitogen-activated protein kinase has been implicated in both skeletal muscle atrophy and hypertrophy. T317 phosphorylation of the p38 substrate mitogen-activated protein kinase-activated protein kinase 2 (MK2) correlates with muscle weight in atrophic and hypertrophic denervated muscle and may influence the nuclear and cytoplasmic distribution of p38 and/or MK2. The present study investigates expression and phosphorylation of p38, MK2 and related proteins in cytosolic and nuclear fractions from atrophic and hypertrophic 6-days denervated skeletal muscles compared to innervated controls.
- Publication
Journal of molecular signaling, 2014, Vol 9, Issue 1, p2
- ISSN
1750-2187
- Publication type
Journal Article
- DOI
10.1186/1750-2187-9-2