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- Title
The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol.
- Authors
Jenkinson, Michael D; Gamble, Carrol; Hartley, John C; Hickey, Helen; Hughes, Dyfrig; Blundell, Michaela; Griffiths, Michael J; Solomon, Tom; Mallucci, Conor L
- Abstract
Insertion of a ventriculoperitoneal shunt (VPS) for the treatment of hydrocephalus is one of the most common neurosurgical procedures in the UK, but failures caused by infection occur in approximately 8% of primary cases. VPS infection is associated with considerable morbidity and mortality and its management results in substantial cost to the health service. Antibiotic-impregnated (rifampicin and clindamycin) and silver-impregnated VPS have been developed to reduce infection rates. Whilst there is some evidence showing that such devices may lead to a reduction in VPS infection, there are no randomised controlled trials (RCTs) to support their routine use.
- Publication
Trials, 2014, Vol 15, p4
- ISSN
1745-6215
- Publication type
Journal Article
- DOI
10.1186/1745-6215-15-4